Überblick:Synopsis Recent evidence proving the molecular link between unchecked chronic inflammation and cancer has implicated the transcription factor NF-kB as a key factor in both inhibiting apoptosis and promoting cell proliferation. Since its initial identification 20 years ago as a simple regulating factor in one small part of the immune response NF-kB is proving to be the most protean of all transcription factors. It has been shown to function in most cell types as a key regulator of a very large number of inducible genes. Research on the many responsibilities and resulting pathologies of NF-kB has been prolific but until now there has been no consolidated multidisciplinary reference.Compiled by Sankar Ghosh who has been involved with much of the breakthrough research the 'Handbook of Transcription Factor NF-kappaB' brings together a range of studies that have recently appeared in the literature. Providing contributions from leading authorities involved with seminal discoveries on the subject this handbook serves as an entry point to understanding the broad role of this widely studied factor.Beginning with a summary the authors introduce the uninitiated reader to the complexities of the NF-kB system. They explain how a multitude of extracellular and intercellular signals integrated at the level of this transcription factor have led to fundamental insights about many aspects of gene regulation and signal transduction.The chapters then delve into specific research aspects concerning the function and regulation of NF-kB in a number of biological systems. They discuss inflammation innate and adaptive immunity liver integrity and nervous system development as well as the formation of hair skin teeth and many other aspects of the developing vertebrate body. The pathological effects of excess NF-kB activity are addressed in chapters on the many diseases related to chronic inflammation such as heart disease muscular dystrophy cancer and tumor proliferation as well as diseases caused by inherent deficiencies in NF-kB. The text culminates in a discussion of current efforts to develop therapies aimed at inhibiting the aberrant activity of NF-kB in different diseases.