Complement Activation in Malaria Immunity and Pathogenesis


Complement Activation in Malaria Immunity and Pathogenesis

Bücher Details

  • Titel:Complement Activation in Malaria Immunity and Pathogenesis
  • Dateiname: complement-activation-in-malaria-immunity-and-pathogenesis.pdf
  • ISBN: 1034973319772570
  • Datum des Hochladens: 2020-01-15
  • Anzahl der Seiten: 496 Seiten
  • Autor: José A. Stoute
  • Verlag: José A. Stoute

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Buchrückseite Plasmodium falciparum malaria is responsible for the deaths of nearly 500000 people each year. Much attention has been paid to antibody and cellular mechanisms of immunity against this pathogen. By contrast the role that the complement system plays in immunity and pathogenesis in this infection is not very well recognized or understood. Based on the work of a number of research groups we know that complement plays an important role in these processes. In this book some of the leading scientists in the field discuss the mechanisms of complement activation during malaria infection as well as the role of complement in the pathogenesis of key syndromes such as severe malarial anemia cerebral malaria and placental malaria. In addition they review recently-identified complement evasion strategies of P. falciparum merozoites and how these mechanisms may translate into paradoxical enhancement of infection rather than protection. Finally they also discuss the role of the mosquito complement system on immunity against the parasite.  Über den Autor und weitere Mitwirkende José A. Stoute M.D. Professor of Medicine and Microbiology & Immunology The Pennsylvania State University Hershey Medical Center and College of Medicine

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