Überblick:Über den Autor und weitere Mitwirkende Helmut Sies M.D. Ph.D.(hon) studied medicine at the Universities of Tübingen Paris and Munich and did the habilitation for physiological chemistry and physical biochemistry at the University of Munich. He spent sabbaticals at the University of Buenos Aires Argentina University of California at Berkeley USA at the University of Siena Italy and the Heart Research Institute Sydney Australia. He was chair of the Department of Biochemistry and Molecular Biology I at Heinrich-Heine-University Düsseldorf Germany where he now is an emeritus professor. He also is senior scientist at the Leibniz Research Institute for Environmental Medicine at Düsseldorf and adjunct professor at the University of Southern California and a professor of biochemistry at King Saud University Riyadh Saudi-Arabia. He served as president of the Society for Free Radical Research International and of the Oxygen Club of California (OCC). He is a Fellow of the National Foundation for Cancer Research (NFCR) Bethesda MD USA and of the Royal College of Physicians (FRCP) London England. He is member of the German National Academy of Sciences Leopoldina. His research interests include hydrogen peroxide metabolism oxidative stress redox signaling and micronutrients notably flavonoids carotenoids and selenium.Regina Brigelius-Flohé received her PhD in Biochemistry in Tübingen and Münster Germany in 1978. During a post-doctoral fellowship in Munich and Düsseldorf together with Helmut Sies she investigated the cellular thiol-disulfide status in perfused organs under various conditions of oxidative stress. The detection and analysis of mixed disulfides of proteins and glutathione provided a basis for the regulation of enzyme activities by thiol modification a field which is now expanding and known as redox regulation. In 1984 changed to pharmaceutical industry and was heading a Molecular Biology Lab and later the Department of Molecular Biology (Grünenthal Ltd. Aachen Germany). In 1994 she became professor at the University of Potsdam combined with the heading of the Department Biochemistry of Micronutrients at the German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE) where she now is an emeritus professor. Her favourite micronutrients were vitamin E and selenium. Her group was the first to elucidate the metabolism of tocopherols and tocotrienols. Research regarding selenium is related to redox-regulated processes in inflammation and cancer development influenced by selenium and specific selenoproteins mainly glutathione peroxidase 2. She was a member of the scientific advisory board of the German Society of Biochemistry and Molecular Biology for 6 years and president of SFRR-Europe 2005/2006. She now serves on the editorial boards of several journals in the field of nutrition micronutrients free radicals and redox regulation.