Atherosclerosis Pathogenesis and Microvascular Dysfunction


Atherosclerosis Pathogenesis and Microvascular Dysfunction

Bücher Details

  • Titel:Atherosclerosis Pathogenesis and Microvascular Dysfunction
  • Dateiname: atherosclerosis-pathogenesis-and-microvascular-dysfunction.pdf
  • ISBN: 1041333030202445
  • Datum des Hochladens: 2020-01-15
  • Anzahl der Seiten: 529 Seiten
  • Autor: Axel Haverich/Erin Colleen Boyle
  • Verlag: Axel Haverich/Erin Colleen Boyle

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Buchrückseite This book provides new perspectives on the pathogenesis of atherosclerosis. Chapters cover atherosclerosis risk factors the effect of growth and aging on vascular architecture and the crucial role the microvasculature plays in atherosclerosis development. Microvascular dysfunction would explain why the well-known risk factors actually put individuals at higher risk. This pathomechanism would also hold true not only for obstructive atheroma formation but also for aneurysmal dilatation as well as for aortic and peripheral artery dissection. When seen through this lens novel preventive and therapeutic opportunities can be envisioned.Atherosclerosis Pathogenesis and Microvascular Dysfunction proposes a single unifying mechanism of atherosclerosis development and describes potential preventative and therapeutic avenues based on this concept. It therefore represents a timely and valuable resource for internal medicine cardiology angiology cardiovascular surgeons pathology clinicians researchers trainees and students. Über den Autor und weitere Mitwirkende Professor Axel Haverich completed his medical training at the MHH and was appointed head of Cardiovascular Surgery at the University of Kiel in 1993. Since 1996 he has been the head of the Department of Cardiothoracic Transplantation and Vascular Surgery at MHH. In 1995 he won the prestigious Leibniz Prize from the German Research Foundation (DFG). With this award he founded the Leibniz Research Laboratories for Biotechnology and Artificial Organs. There the foundation was laid for many scientific achievements including bioengineered heart valves that grow with the patient and a bioengineered vascular graft for coronary reconstruction based on an autologous fibrin matrix.  His company “CorLife” has provided >250 decellularized heart valves to children and adolescents. Here two clinical trials have been funded by EU grants.  He has been granted several patents in the field of tissue engineering such as for a biological vascularized autologous matrix which can replace damaged myocardium. Prof. Haverich served as the coordinator of the Excellence Cluster “From Regenerative Biology to Reconstructive Therapy” from 2006 to 2018. In addition to being the Chairman of the German Society for Thoracic and Cardiovascular Surgery from 2007-2009 he was the president of the German Society of Surgery from 2010 to 2011. He has published over 1000 peer-reviewed papers and has contributed to numerous books.Dr. Erin Colleen Boyle received her Bachelor of Science (Specialized Honors Microbiology) from the University of Guelph and her PhD from the Department of Microbiology and Immunology at the University of British Columbia. She was awarded an Alexander von Humboldt Postdoctoral Research Fellowship in 2010. In 2015 Dr. Boyle joined the Department of Cardiothoracic Transplantation and Vascular Surgery at Hannover Medical School (MHH). She has published numerous primary research and review papers in high-level peer-reviewed journals on the topics of bacterial pathogenesis and atherosclerosis.

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